ArticlePreventive medicine reports2025
Trends in the prevalence of early-onset cancer and associated early-life exposures among US adults: A serial cross-sectional study.
Article in Preventive medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Individual preferences for the design of a health coaching-based lifestyle promotion program among middle-aged adults in Hong Kong: a discrete choice experiment.Health and quality of life outcomes · 2026Article
- Nutrition Across the Life Course and Risk of Young-Onset Breast Cancer: Mechanisms, Evidence, and Prevention Opportunities.Nutrients · 2026Review
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2 authors.
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Abstract
Objectives: This study aimed to investigate trends in the prevalence of early-onset cancer and its association with early-life exposure among US adults. Methods: This cross-sectional study utilized data from 10 survey cycles between 1999 and 2018 from the National Health and Nutrition Examination Survey (NHANES). Early-onset cancer was defined as the first malignancy diagnosed between the ages of 20 and 49. We conducted trend analyses to assess the prevalence of cancer and early-life exposures. Early-life exposures included diabetes, smoking, overweight and obesity that was experienced before the age of 50. Weighted logistic regression models were employed to identify associations between early-life exposure and early-onset cancer. The outcomes were average biennial percent changes (ABPCs), odds ratios (ORs) and 95 % confidence intervals (CIs). Results: The prevalence of early-onset cancer increased significantly from 2.4 % (95 % CI: 2.0-3.1 %) in 1999-2000 to 3.9 % (95 % CI: 3.0-4.9 %) in 2017-2018, corresponding to an ABPC of 3.7 (95 % CI: 0.8 to 6.6). This increase was primarily observed in non-sex-specific cancers and men. With the exception of smoking, the prevalence of all early-life exposures increased significantly. Early-onset diabetes (OR 1.56, 95 % CI: 1.15-2.12) and early-life smoking (OR 1.55, 95 % CI: 1.34-1.80) were positively associated with early-onset cancer, whereas early-life obesity (OR 0.64, 95 % CI: 0.52-0.79) was negatively associated with early-onset cancer. Conclusion: The prevalence of early-onset cancer increased significantly among US adults between 1999 and 2018. Early-onset diabetes and early-life smoking are positively associated with early-onset cancer, whereas early-life obesity is negatively associated with early-onset cancer.
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