Evidence map›Paper›PMID 41625499›Full record

ArticleBioactive materials2026

Bioactive-coated porous anastomotic staples enhance anastomotic healing.

Renjie Li, Qi Sun, Ruijun Xu, Runlong Zhu, Jiarui Lin, Qijing Tang, Qihuan Zhou, Yong Li, Feng Wang, Zifeng Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Renjie LiGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Qi SunDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Ruijun XuDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Runlong ZhuDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Jiarui LinDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Qijing TangDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Qihuan ZhouDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Yong LiGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
Feng WangDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.
Zifeng YangDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Titanium (Ti) staples used for digestive tract reconstruction often suffer from delayed anastomotic healing and increased complication rate due to insufficient surface bioactivity. In this study, we combine a micro/nano porous Ti (Ti-OH) with an electrochemically co-deposited polydopamine (PDA) bioactive coating to construct vascular endothelial growth factor (VEGF) high loading and stage-adaptive release staples (Ti-OH-ePV). Alkali heat treatment generates hydroxyl groups and a micro/nano porous structure on the surface of Ti staples, which enhances the combination between the coating and the Ti-OH, increasing the loading capacity for VEGF. Electrochemical co-deposition embeds VEGF within the PDA network, further improving VEGF loading. Importantly, the PDA coating exhibits pH-responsive release

Indexed as

Anastomotic healingBioactive coatingTi stapleVEGF release

Identifiers

PMID41625499
PMCPMC12856637

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.