Evidence map›Paper›PMID 41625498›Full record

ArticleBioactive materials2026

Apolipoprotein E knockout attenuates vascular graft fibrosis by reducing profibrotic macrophage formation through low-density lipoprotein receptor related protein 1.

Jiayin Fu, Meng Zhao, Jing Zhao, Shaofei Wu, Jiahui Wu, Xulin Hong, He Huang, Guosheng Fu, Shengjie Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiayin FuDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
Meng ZhaoDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
Jing ZhaoDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
Shaofei WuDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
Jiahui WuSchool of Medicine, Shaoxing University, Shaoxing, 312000, China.
Xulin HongDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
He HuangDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
Guosheng FuDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.
Shengjie XuDepartment of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, 310016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular graft fibrosis can cause a decrease in cellular infiltration and capillary ingrowth in vascular walls. It can also lead to vascular stiffening. As such, there are still no vascular grafts that can be used in blood vessels where their diameters are less than 6 mm in patients. Although various approaches have been evaluated to mitigate implant-associated fibrosis, effective treatments remain quite limited. In this study, we demonstrated that Apolipoprotein E (APOE) significantly increased during vascular regeneration after graft implantation

Indexed as

APOEFibrosisLRP1Profibrotic macrophageVascular graft

Identifiers

PMID41625498
PMCPMC12860263

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.