Evidence map›Paper›PMID 41625446›Full record

ArticleNeurobiology of stress2026

Ventral pallidum GABA neuron inhibition augments context-appropriate defensive responses to learned threat cues.

Erica M Ramirez, Maricela X Martinez, Ryan K Rokerya, Vanessa Alizo Vera, Christina M Ruiz, Mitchell R Farrell, Shreeya A Walawalkar, Hazael Ramirez-Ramirez, Grace J Kollman, Stephen V Mahler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of stress, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Unpacking Ventral Pallidum GABA Neuron Contributions to Opioid Drug Reward in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Erica M RamirezDepartment of Neurobiology & Behavior, University of California, Irvine, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
Maricela X MartinezDepartment of Neurobiology & Behavior, University of California, Irvine, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
Ryan K RokeryaDepartment of Neurobiology & Behavior, University of California, Irvine, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
Vanessa Alizo VeraDepartment of Neurobiology & Behavior, University of California, Irvine, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
Christina M RuizDepartment of Neurobiology & Behavior, University of California, Irvine, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
Mitchell R FarrellDepartment of Neurobiology & Behavior, University of California, Irvine, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
Shreeya A WalawalkarDepartment of Neurobiology & Behavior, University of California, Irvine, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
Hazael Ramirez-RamirezDepartment of Neurobiology & Behavior, University of California, Irvine, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
Grace J KollmanDepartment of Neurosciences, University of California, San Diego, 9375 Gilman Dr, San Diego, CA, 92161, USA.
Stephen V MahlerDepartment of Neurobiology & Behavior, University of California, Irvine, 1203 McGaugh Hall, Irvine, CA, 92697, USA.

Funding

Impact of Cannabinoid Across the Lifespan (ICAL)P50DA044118 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine M Gall · 2018 to 2026
$18.2M
Dynamic epigenomic landscape of opioid abuse following early-life adversityU01DA053826 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Tallie Z. Baram, CHRISTIE D FOWLER · 2022 to 2026
$3.4M
On circuit mechanisms of reward behaviors after early-life adversityRF1MH132680 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z., CHEN, YUNCAI · 2025 to 2025
$2.1M
Ventral Pallidum Circuits Underlying Preclinical Models of Opioid AddictionR01DA055849 · NIDA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Stephen Vincent Mahler · 2023 to 2026
$1.4M
On circuit mechanisms of reward behaviors after early-life adversityR01MH132680 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BARAM, TALLIE Z., CHEN, YUNCAI · 2023 to 2024
$1.3M
Persistent Impacts of Adolescent THC on Microglial Function and Opioid Addiction RiskF99NS141399 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARTINEZ, MARICELA XOCHIL · 2024 to 2025
$94k
Ventral Pallidum Circuits in Motivation, Risky Decision Making, and Opioid AddictionF99NS120641 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI FARRELL, MITCHELL · 2020 to 2021
$85k
NIDA NIH HHS P50 DA044118NIDA NIH HHS R01 DA055849NIDA NIH HHS U01 DA053826NIMH NIH HHS R01 MH132680NIMH NIH HHS RF1 MH132680NINDS NIH HHS F99 NS120641NINDS NIH HHS F99 NS141399
6 · The paper itself

Abstract

The ventral pallidum (VP) is embedded within the brain circuits controlling motivated behavior, which are heavily implicated in addiction and other psychiatric disorders. Prior work showed that VP GABAergic neurons (VP

Indexed as

Aversive motivationDefensive treadingFear conditioningLateral habenulaMediodorsal thalamus

Identifiers

PMID41625446
PMCPMC12859806

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.