Evidence map›Paper›PMID 41625384›Full record

ArticleMaterials today. Bio2025

Clinically friendly smart hydrogel boosts cuproptosis and PD-L1 upregulation to enhance anti-tumor immunotherapy.

Baiyang Fu, Guangyan Li, Yuan Yao, Mingfu Zhang, Yesheng Zhong, Xi Wang, Yichi Chen, Wenlong Liang, Yao Wang, Haiyun Lin and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Baiyang FuDepartment of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150000, China.
Guangyan LiDepartment of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150000, China.
Yuan YaoDepartment of Ultrasound, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150000, China.
Mingfu ZhangNational Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Harbin Institute of Technology, No. 92 Xidazhi Street, Harbin, 150000, China.
Yesheng ZhongNational Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Harbin Institute of Technology, No. 92 Xidazhi Street, Harbin, 150000, China.
Xi WangDepartment of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150000, China.
Yichi ChenDepartment of Ultrasound, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Harbin, 150000, China.
Wenlong LiangDepartment of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150000, China.
Yao WangDepartment of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150000, China.
Haiyun LinDepartment of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150000, China.
Yutong ZhangDepartment of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150000, China.
Qiguang DuDepartment of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150000, China.
Zhongkai XuDepartment of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150000, China.
He CuiDepartment of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150000, China.
Liping ShiNational Key Laboratory of Science and Technology on Advanced Composites in Special Environments, Harbin Institute of Technology, No. 92 Xidazhi Street, Harbin, 150000, China.
Xi ChenDepartment of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150000, China.
Jianguo ZhangDepartment of Breast Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Harbin, 150000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) faces the challenge of limited treatment efficacy due to its highly invasive ability and its immunosuppressive microenvironment. This study found that cuproptosis, as an emerging therapeutic strategy, has unique therapeutic potential in TNBC. Nevertheless, the delivery difficulties of cuproptosis-inducing agents and the limited efficacy of single drugs restrict the clinical application of cuproptosis therapy. Herein, a temperature/pH dual-responsive composite hydrogel was developed to load Elesclomol-Cu (ES-Cu) and glucose oxidase (GOx) (ES-Cu&GOx@FFC). ES and Cu

Indexed as

Cancer immunotherapyCuproptosisHydrogelPD-L1TNBC

Identifiers

PMID41625384
PMCPMC12859559

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.