Evidence map›Paper›PMID 41625380›Full record

ArticleMaterials today. Bio2025

Biomolecule-tailored chiral nickel oxide nanozymes amplify autophagy-mediated tumor ablation via synergistic photodynamic-chemodynamic therapy.

Wei Pang, Yining Shao, Hefeng Xu, Tianqi Li, Linxuan Wu, Zhipeng Liu, Lei Zhang, Wei Chen, Yiwen Li, Dake Xu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wei PangKey Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Intelligent Medicine, China Medical University, Shenyang, 110122, China.
Yining ShaoDepartment of Plastic Surgery, The First Hospital of China Medical University, Shenyang, 110002, China.
Hefeng XuKey Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Intelligent Medicine, China Medical University, Shenyang, 110122, China.
Tianqi LiKey Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Intelligent Medicine, China Medical University, Shenyang, 110122, China.
Linxuan WuKey Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Intelligent Medicine, China Medical University, Shenyang, 110122, China.
Zhipeng LiuSchool of Materials Science and Engineering, Hubei University, Wuhan, 430062, China.
Lei ZhangSchool of Materials Science and Engineering, Hubei University, Wuhan, 430062, China.
Wei ChenCollege of Engineering Physics, Shenzhen Technology University, Shenzhen, 518118, China.
Yiwen LiSchool of Materials Science and Engineering, Hubei University, Wuhan, 430062, China.
Dake XuSchool of Materials Science and Engineering, Northeastern University, Shenyang, 110819, China.
Jiaji ChengSchool of Materials Science and Engineering, Hubei University, Wuhan, 430062, China.
Xiaoqian XuKey Laboratory of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, School of Intelligent Medicine, China Medical University, Shenyang, 110122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chiral nanomaterial-mediated phototherapy has attracted attention as an emerging tumor treatment method. In this study, we synthesized chiral nickel oxide (L/D-Cys-NiO) photosensitizers via surface modulation using chiral cysteine molecules, thereby improving the biocompatibility and significantly enhancing the efficacy of photodynamic-chemodynamic therapy. L/D-Cys-NiO can selectively stimulate the production of reactive oxygen species and hydroxyl radicals, providing synergistic therapy in tumor cells with 4-5-fold greater efficacy than conventional phototherapy. L/D-Cys-NiO can also effectively prevent the infiltrative growth and metastasis of tumor cells by reducing their migration and invasiveness by nearly 40 %.

Indexed as

Antitumor therapyChiral nickel oxideEnantioselectivityPhotodynamic-chemodynamic therapyPhotosensitizer

Identifiers

PMID41625380
PMCPMC12859675

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.