Evidence map›Paper›PMID 41625374›Full record

ArticleMaterials today. Bio2025

Multilayer dual-porosity 3D printed scaffolds to recreate the anisotropic microenvironment of the hyaline cartilage.

Sandra Ramos-Díez, Luis Diaz-Gomez, Maria Paulis, Sandra Camarero-Espinosa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sandra Ramos-DíezBioSmarTE Lab, POLYMAT, University of Basque Country UPV/EHU, Av. de Tolosa, 72, 20018, Donostia-San Sebastián, Spain.
Luis Diaz-GomezDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782, Santiago de Compostela, Spain.
Maria PaulisKimika Aplikatua saila, Kimika Fakultatea, POLYMAT, University of Basque Country UPV/EHU, Av. de Tolosa, 72, 20018, Donostia-San Sebastián, Spain.
Sandra Camarero-EspinosaBioSmarTE Lab, POLYMAT, University of Basque Country UPV/EHU, Av. de Tolosa, 72, 20018, Donostia-San Sebastián, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Articular cartilage accounts for a multizonal structure with distinct matrix composition and chondrogenic phenotypes, responsible for the tissue's load-bearing ability. Upon damage, cartilage is clinically treated by microfracture, which allows bone marrow exudation to the previously abraded zone. However, mesenchymal stem cells (hMSC) of the marrow cannot differentiate into specific chondrogenic phenotypes and the resulting tissue is isotropic and non-functional. Here, we developed multilayer dual-porosity scaffolds with defined in-fiber and structural porosities that were able to steer hMSC's differentiation into specific chondrogenic phenotypes. A library of inks prepared from poly-(

Indexed as

3D printingAnisotropic structuresHyaline cartilageMesenchymal stem cellsPorous scaffoldstissue engineering

Identifiers

PMID41625374
PMCPMC12859601

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.