Evidence map›Paper›PMID 41625372›Full record

ArticleMaterials today. Bio2025

A H

Chunru Kong, Chao Si, Haofeng Liu, Yawen Wang, Jiakai Qiao, Xiaoduo Tang, Hongchen Sun, Junhu Zhang, Bei Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Biointegrated Battery-Based Electroceuticals.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chunru KongHospital of Stomatology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University, Changchun, 130021, China.
Chao SiHospital of Stomatology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University, Changchun, 130021, China.
Haofeng LiuHospital of Stomatology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University, Changchun, 130021, China.
Yawen WangHospital of Stomatology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University, Changchun, 130021, China.
Jiakai QiaoHospital of Stomatology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University, Changchun, 130021, China.
Xiaoduo TangHospital of Stomatology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University, Changchun, 130021, China.
Hongchen SunHospital of Stomatology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University, Changchun, 130021, China.
Junhu ZhangJoint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun, 130021, China.
Bei ChangHospital of Stomatology, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University, Changchun, 130021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The repair of infected bone defects (IBDs) presents a significant clinical challenge due to recurrent infections and inflammation. Characterized by reactive oxygen species (ROS) bursts and mitochondrial dysfunction, IBDs generates to a vicious oxidation-inflammation cycle that impairs bone remodeling. To address this, we developed a double-network hydrogel scaffold composed of phenylboronic acid-modified quaternary chitosan and glycidyl methacrylated poly(vinyl alcohol) (QP-P), crosslinked via dynamic boronic ester bonds and covalent bonds, loaded with magnesium microspheres (Mg spheres) (QP-P/Mg). This double-crosslinking network confers excellent injectability and tissue adhesion while integrating potent antibacterial, ROS-scavenging, pro-angiogenic, and osteogenic functions. Notably, Mg spheres enable controlled hydrolysis through a boronic ester-magnesium ion (Mg

Indexed as

HydrogenInfected bone defectsMitochondrial rehabilitationNrf2/HO-1 pathwayRegeneration

Identifiers

PMID41625372
PMCPMC12859556

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.