Evidence map›Paper›PMID 41625371›Full record

ArticleMaterials today. Bio2025

Macrophage-related immune responses to polyetherketoneketone bone implants: Single-cell transcriptome analysis.

Jiannan Zhou, Huibin Liang, Jiahao Chen, An Li, Jingtao Dai, Ping Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiannan ZhouSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China.
Huibin LiangSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China.
Jiahao ChenDepartment of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
An LiDepartment of Periodontology, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Jingtao DaiDepartment of Orthodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Ping LiSchool and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyetherketoneketone (PEKK) has emerged as a potential alternative to titanium (Ti) for bone implants. Nevertheless, its osseointegration performance is inferior to that of Ti, primarily due to the limited understanding of its early immune reactions. To address this limitation, this study utilized single-cell RNA sequencing to investigate the distinct early macrophage responses triggered by Ti-based and PEKK-based implants. This approach enabled the characterization of macrophage-polarization dynamics and intercellular interactions within the bone-marrow microenvironment post-implantation. The findings revealed a material-dependent dichotomy in macrophage phenotype: Ti implants preferentially recruited

Indexed as

BoneMacrophagePolyetherketoneketoneRNA sequencingTitanium

Identifiers

PMID41625371
PMCPMC12859614

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.