Evidence map›Paper›PMID 41625245›Full record

ArticleFrontiers in endocrinology2025

Insulin-like growth factor 1 (IGF-1)-induced changes in cardiac inducible nitric oxide synthase (iNOS) in obese rats.

Sonja Zafirovic, Milan Obradovic, Katarina Banjac, Emina Sudar-Milovanovic, Anastasija Pajcin, Jelena Radovanovic, Esma R Isenovic

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In one paragraph

Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Sonja ZafirovicDepartment of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Milan ObradovicDepartment of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Katarina BanjacDepartment of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Emina Sudar-MilovanovicDepartment of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Anastasija PajcinDepartment of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Jelena RadovanovicDepartment of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.
Esma R IsenovicDepartment of Radiobiology and Molecular Genetics, VINČA Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The role of insulin-like growth factor 1 (IGF-1) in preserving cardiovascular (CV) health, a well-established fact, cannot be overstated. IGF-1 affects inducible nitric oxide synthase (iNOS) activity, contributing to metabolic homeostasis by promoting insulin and glucose metabolism. Excessive iNOS production is involved in the occurrence and progression of insulin resistance and CV diseases (CVD). This study aimed to assess the Methods: Male adult Wistar rats were fed a standard (Control) or a high-fat (HF) diet for 12 weeks. After the 12 Results: The Discussion: Our findings suggest that the treatment of obese rats with IGF-1 could have significant implications for cardiac function, particularly in the context of obesity, by regulating cardiac iNOS.

Indexed as

Insulin-Like Growth Factor IMyocardiumNitric Oxide Synthase Type IIObesityAnimalsDiet, High-FatMaleMAP Kinase Signaling SystemRatsRats, Wistarinsulin-like growth factor-1, ratInsulin-Like Growth Factor INitric Oxide Synthase Type IINos2 protein, ratheartIGF-1iNOSNOobesity

Identifiers

PMID41625245
PMCPMC12855136

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.