Evidence map›Paper›PMID 41625241›Full record

ReviewFrontiers in endocrinology2025

Mondo family proteins in diabetes.

Sandeep Kumar Barodia, Maria B Grant, Marina S Gorbatyuk

Abstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sandeep Kumar BarodiaDepartment of Biochemistry, Wake Forest University Medical School, Winston-Salem, NC, United States.
Maria B GrantDepartment of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, United States.
Marina S GorbatyukDepartment of Biochemistry, Wake Forest University Medical School, Winston-Salem, NC, United States.

Funding

NITRIC OXIDE IN THE PATHOGENESIS OF DIABETIC RETINOPATHYR01EY012601 · NEI · UNIVERSITY OF FLORIDA · PI Julia V Busik, Maria Bartolomeo Grant · 1998 to 2026
$9.6M
NEI NIH HHS R01 EY012601
6 · The paper itself

Abstract

Carbohydrate-responsive element binding protein (ChREBP) and Max-like protein X (MLX) are key Mondo Family Proteins (MFPs) acting as transcription factors. They are known to couple intracellular sugar levels with carbohydrate and lipid metabolism by regulating glucose-responsive gene expression. MondoA regulates lipid metabolism and insulin signaling in addition to controlling glucose uptake, whereas ChREBP primarily regulates

Indexed as

Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsDiabetes MellitusGene Expression RegulationGlucoseGlycolysisHumansLipid MetabolismBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsGlucoseMLXIPL protein, humanMLX protein, humanChREBPdiabetesglucose metabolisminsulin resistanceMondoA

Identifiers

PMID41625241
PMCPMC12852010

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.