ArticleSurgical neurology international2025
Senile thoracolumbar tuberculosis with kyphosis and severe osteoporosis treated with polymethylmethacrylate-augmented screw fixation.
Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Elderly osteoporotic patients with kyphosis secondary to spinal tuberculosis (TB) are at high risk for implant failure. For these patients, polymethylmethacrylate (PMMA)-augmented pedicle screw fixation provides immediate stability but increases the risk of infection. Here, we evaluated the outcome for a 78-year-old osteoporotic female with TB-related kyphosis successfully managed with PMMA-augmented pedicle screw fusion. Case Description: A 78-year-old female presented with mid-back pain, progressive kyphotic deformity, and increasing paraparesis. The magnetic resonance imaging revealed infectious T12-L1 spondylitis with accompanying vertebral body destruction/kyphosis. She underwent a single-stage posterior PMMA-augmented screw fixation from T9-L4 supplemented with anterior reconstruction and cage/bone grafting. The histology/cultures were consistent with spinal TB for which she received anti-tuberculosis therapy, followed by once weekly teriparatide (60 µg for 6 weeks). Neurological recovery was complete within 3 months, and by 2 years, the imaging confirmed a stable fusion. Conclusion: A 78-year-old osteoporotic female with T12/L1 TB-related spondylitis successfully underwent selective PMMA-augmented pedicle screw fixation from T9-L4 supplemented with anti-tubercular therapy.
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