Evidence map›Paper›PMID 41624940›Full record

ArticleRSC advances2026

A synergistic dual-mode biosensor for methotrexate detection leveraging FRET and Ag NP-based UV absorption.

Qiongdan Zhang, Qiongwei Teng, Huihong Duan, Caiyun Peng, Wenbing Sheng, Wei Wang, Bin Li

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiongdan ZhangTCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine Changsha China wangwei402@hotmail.com libin@hnucm.edu.cn +86 15874100917 +86 13657438606.
Qiongwei TengTCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine Changsha China wangwei402@hotmail.com libin@hnucm.edu.cn +86 15874100917 +86 13657438606.
Huihong DuanTCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine Changsha China wangwei402@hotmail.com libin@hnucm.edu.cn +86 15874100917 +86 13657438606.
Caiyun PengTCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine Changsha China wangwei402@hotmail.com libin@hnucm.edu.cn +86 15874100917 +86 13657438606.
Wenbing ShengTCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine Changsha China wangwei402@hotmail.com libin@hnucm.edu.cn +86 15874100917 +86 13657438606.
Wei WangTCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine Changsha China wangwei402@hotmail.com libin@hnucm.edu.cn +86 15874100917 +86 13657438606.ORCID https://orcid.org/0000-0003-0876-2205
Bin LiTCM and Ethnomedicine Innovation & Development International Laboratory, School of Pharmacy, Hunan University of Chinese Medicine Changsha China wangwei402@hotmail.com libin@hnucm.edu.cn +86 15874100917 +86 13657438606.ORCID https://orcid.org/0009-0005-6265-782X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel dual-mode sensing platform (DMSP) integrating fluorescence and ultraviolet (UV) detection was developed for the sensitive and accurate quantification of methotrexate (MTX). This approach combines a FRET-based fluorescent "turn-on" mechanism, employing FAM as the fluorophore and BHQ as the quencher, with a UV absorption mode utilizing the unique surface plasmon resonance properties of silver nanoparticles (Ag NPs). The fluorescence mode enables highly sensitive detection

Identifiers

PMID41624940
PMCPMC12856982

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.