ArticleRSC advances2026
Enhanced controlled drug delivery of berberine-loaded gelatin nanoparticles: characterization and
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Green Synthesis of Oat-Derived Carbon Quantum Dot/Gelatin Hydrogel Scaffolds: Enhanced Structural Stability and Bioactivity for Potential Bone Repair.Gels (Basel, Switzerland) · 2026Article
- Cellular and Molecular Mechanisms of Berberine in Cancer Therapy: Recent Advances.Archiv der Pharmazie · 2026Review
- Sequential eradication of bacterial persisters: integrating phytochemical pharmacology with microenvironment-responsive delivery strategies.Frontiers in microbiology · 2026Review
- Parenteral Berberine vs Cisplatin- Loaded Lipid Nanoparticles - Development, Characterisation, Comparative Safety Profiling and Cytotoxicity in Cholangiocarcinoma Cell Models.Nanotechnology, science and applications · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Berberine (BBR), a natural isoquinoline alkaloid, has long been recognized for its potent antimicrobial properties. However, BBR's therapeutic potential remains limited due to its poor bioavailability, low solubility, and short biological half-life. Nanoencapsulation of BBR within a suitable carrier system represents a promising strategy to overcome these limitations and enhance its pharmacological performance. In this study, BBR-loaded gelatin nanoparticles (BBR-GNPs) were successfully synthesized using a double desolvation technique to achieve controlled release and improved antimicrobial efficacy. FTIR and XRD spectroscopy affirmed the loading of BBR in GNPs. The prepared BBR-GNPs exhibited a mean particle size of 215.4 ± 54.32 nm and a zeta potential of +22.6 ± 4.48 mV, as determined by dynamic light scattering (DLS), with an encapsulation efficiency of 72.5%. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses revealed uniformly spherical nanoparticles with an average size of 169.4 ± 25.89 nm.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.