ArticleFrontiers in microbiology2026
Dual RNA-Seq analysis unveils the multifaceted mechanisms of
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- The KeyPlants (Basel, Switzerland) · 2026Article
- Transcriptomic insights into the biocontrol mechanism of Trichoderma spp. against Fusarium wilt in melon.Stress biology · 2026Article
- Molecular Mechanisms and Metabolic Responses in the Biological Antagonism BetweenMicroorganisms · 2026Article
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9 authors.
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Abstract
Background: Fusarium head blight (FHB), caused by Objective: This study aimed to investigate the antagonistic potential of Methods: Antagonistic activity was assessed via dual-culture and pot experiments with wheat seedlings under four treatments: control (CK), Th, Fg, and dual inoculation (Th-Fg). Transcriptome sequencing (RNA-seq) data were aligned to the genomes of Fg, Trichoderma guizhouense (as a proxy for Th), and Results: Both assays showed Th strongly inhibited Fg growth. RNA-seq revealed that under Th pressure (Fg vs. Th-Fg), Fg exhibited widespread transcriptional suppression, with 608 DEGs downregulated and enriched in carbohydrate metabolism, indicating disrupted nutrient acquisition. Th itself showed minimal transcriptional changes (Th vs. Th-Fg), suggesting a resource-efficient strategy. Fg infection (CK vs. Fg) suppressed wheat photosynthesis and carbon metabolism, while Th inoculation (CK vs. Th) primed defense pathways. In the dual inoculation, Th alleviated Fg-induced suppression and enhanced wheat defense and physiological gene expression. qRT-PCR validated the RNA-seq reliability. Conclusion:
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