SynthesisFrontiers in immunology2025
Global research landscape of ferroptosis in gastric cancer: a multidisciplinary bibliometric analysis based on multiple databases (2017-2025).
Synthesis in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Bibliometric and Latent Dirichlet Allocation (LDA) analysis of artificial intelligence for thyroid nodules.Frontiers in endocrinology · 2026Pooled it
- Bibliometric analysis of neurite orientation dispersion and density imaging: research patterns, evolution, and frontier.Frontiers in neuroscience · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Ferroptosis, an iron-dependent regulated cell death mechanism, has recently gained attention for its crucial role in tumor progression and immune regulation. Gastric cancer (GC), one of the most common and deadly malignancies worldwide, remains a major clinical challenge. This study aims to systematically analyze the global research landscape, hotspots, and trends of ferroptosis in gastric cancer from 2017 to 2025, with a focus on its immunological implications. Methods: Publications related to ferroptosis and gastric cancer published between January 1, 2017 and April 22, 2025 were retrieved from the Web of Science Core Collection (WoSCC) and Scopus databases (n = 974). Bibliometric and visualization analyses were performed using R software (bibliometrix package), VOSviewer, and CiteSpace to explore publication trends, collaboration patterns, keyword co-occurrence, and thematic evolution. Results: Research output showed a continuous upward trend, with China leading in publication volume, followed by the United States, Japan, Canada, and South Korea. Frontiers in Pharmacology and Frontiers in Oncology were the most productive journals, while Cell and Nature were the most frequently cited. The most prominent themes included "immune checkpoint," "tumor immune microenvironment," "ferroptosis mechanisms," "drug resistance," and "non-coding RNAs." Notably, the STAT3-ferroptosis axis and immune pathways were identified as key translational targets. Conclusion: Ferroptosis has become an important research frontier in gastric cancer and is increasingly recognized as a promising therapeutic strategy to modulate the tumor immune microenvironment and enhance immunotherapy efficacy. This study provides a comprehensive overview of the global research landscape, offering valuable guidance for future studies in cancer immunology and ferroptosis-based therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.