Case Report: Murine typhus complicated by symmetrical peripheral gangrene: first report and diagnostic insights from metagenomic next-generation sequencing.

Hengling Zhu, Linhui Hu, Zaiming Feng, Zichen Zhang, Hengbao Zhu, Huihua Li

Abstract readCase Reports

In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hengling Zhu *Department of Critical Care Medicine, Maoming People's Hospital, Maoming, Guangdong, China.

Linhui Hu *Department of Critical Care Medicine, Maoming People's Hospital, Maoming, Guangdong, China.

Zaiming Feng *Department of Critical Care Medicine, Maoming People's Hospital, Maoming, Guangdong, China.

Zichen ZhangChildren's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Hengbao ZhuDepartment of Pharmacy, Maoming People's Hospital, Maoming, Guangdong, China.

Huihua LiDepartment of Critical Care Medicine, Maoming People's Hospital, Maoming, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Murine typhus, a flea-borne infection caused by Case presentation: A 69-year-old female from South China was hospitalized with persistent abdominal pain and low-grade fever. She was a farmer and had suspected animal exposure. Laboratory investigations revealed hypoxia, abnormal coagulation profile, hepatorenal impairment, and thrombocytopenia. Despite empirical antibiotic therapy, her condition deteriorated progressively, manifested as hemodynamic instability, respiratory failure, and the emergence of purpuric-petechial cutaneous eruptions. Immediate interventions were initiated, including administration of vasoactive agents and mechanical ventilation. Based on mNGS, Conclusion: This first reported case of murine typhus complicated by symmetrical peripheral gangrene (SPG) establishes its potential to cause life-threatening multiorgan failure. Metagenomic next-generation sequencing (mNGS) resolved the diagnostic challenge by rapidly identifying

Indexed as

GangreneRickettsia typhiTyphus, Endemic Flea-BorneAgedAnimalsAnti-Bacterial AgentsDoxycyclineFemaleHigh-Throughput Nucleotide SequencingHumansMetagenomicsAnti-Bacterial AgentsDoxycyclinemetagenomic next-generation sequencing (mNGS)multiple organ dysfunctions (MODS)murine typhusRickettsia typhi (R. typhi)symmetrical peripheral gangrene (SPG)

Identifiers

PMID41624871

DOI10.3389/fimmu.2025.1746919

PMCPMC12855535

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.