ReviewFrontiers in immunology2025
Glutamine metabolism remodels tumor-associated macrophage: mechanistic explorations and new strategies in translational medicine.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Macrophage trained immunity requires a mitochondrial glutamine-restriction checkpoint for antitumor protection in mice.Nature communications · 2026Article
- 70 Years of DON and Beyond: Glutaminase Inhibition as a Synergistic Strategy in Cancer Combination Therapy.Pharmaceutics · 2026Review
- Nrf2 Activation Alleviates Silica-Induced Toxicity in Alveolar Macrophages via Glutamine Metabolic Reprogramming.Toxics · 2026Article
- Novel Perspective for Prognostic Stratification and Personalized Therapy in Breast Cancer Patients: Development of Cancer Stem Cells and Metabolism-Associated Prognostic Model.International journal of women's health · 2026Article
- Macrophage-Orchestrated Metabolic Sensing Drives IBD Pathogenesis: A Framework for Targeted Therapy.International journal of biological sciences · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Glutamine metabolism provides energy and raw materials for tumor survival and proliferation. In addition to affecting cancer cells, many studies have investigated the role of glutamine metabolism on the tumor microenvironment in depth. The macrophages, which show high frequently distribution in the majority of solid tumors, are important immune cells in the tumor microenvironment. Tumor-associated macrophage metabolic network remodeling is enormous and complicated. This review links TAM with glutamine metabolism, and combs the network relationship between the unique functional state of macrophages and the key programs of glutamine metabolism in terms of epigenetic modification, signaling pathway transduction, and metabolic checkpoint regulation. In addition, we will summarize the existing glutamine metabolism-targeting drugs and explore the new technologies and strategies for glutamine metabolism to regulate the functional state of TAM.
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