Evidence map›Paper›PMID 41624859›Full record

ArticleFrontiers in immunology2025

Transpresentation of interleukin 15 by stromal cell subsets regulates immune cell homeostasis.

Carmen Stecher, Romana Bischl, Elisabeth Potzmann, Anna Schmid-Böse, Stefanie Ferstl, Nina Braun, Ellen R Richie, Matthias Farlik, Richard A Flavell, Dietmar Herndler-Brandstetter

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carmen StecherCenter for Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.
Romana BischlCenter for Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.
Elisabeth PotzmannCenter for Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.
Anna Schmid-BöseCenter for Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.
Stefanie FerstlCenter for Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.
Nina BraunCenter for Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.
Ellen R RichieDepartment of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston TX, United States.
Matthias FarlikDepartment of Dermatology, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.
Richard A FlavellDepartment of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven CT, United States.
Dietmar Herndler-BrandstetterCenter for Cancer Research, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stromal cells are important bone marrow (BM) niche components that regulate immune cell homeostasis through the production of cytokines such as interleukin 15 (IL-15). Although stromal-derived IL-15 is known to support lymphocyte survival, it remains unclear which stromal cell subsets are capable of IL-15 transpresentation, and how they influence specific lymphocyte populations. By using conditional IL-15 receptor alpha (IL-15Rα) deletion models, we demonstrate that IL-15Rα expression by BM stromal cells is essential for the maintenance of multiple IL-15-dependent lymphocyte populations. Deletion of IL-15Rα in Lepr

Indexed as

HomeostasisInterleukin-15Mesenchymal Stem CellsStromal CellsAnimalsCD8-Positive T-LymphocytesImmunologic MemoryInterleukin-15 Receptor alpha SubunitKiller Cells, NaturalMiceMice, Inbred C57BLMice, KnockoutNatural Killer T-CellsReceptors, Interleukin-15Il15ra protein, mouseInterleukin-15Interleukin-15 Receptor alpha SubunitReceptors, Interleukin-15bone marrow nicheCD8 T cellsIL-15Rαinterleukin 15mesenchymal stromal cellsNK cells

Identifiers

PMID41624859
PMCPMC12855473

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.