Evidence map›Paper›PMID 41624796›Full record

ArticleAdvanced functional materials2025

Engineering the microstructure and spatial bioactivity of MAP scaffolds instructs vasculogenesis in vitro and modifies vessel formation in vivo.

Alexa R Anderson, Eleanor L P Caston, Lindsay Riley, Long Nguyen, Dimitris Ntekoumes, Sharon Gerecht, Tatiana Segura

Abstract read
In one paragraph

Article in Advanced functional materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexa R AndersonDepartment of Biomedical Engineering, Duke University, Durham, NC 27705, USA.
Eleanor L P CastonDepartment of Biomedical Engineering, Duke University, Durham, NC 27705, USA.
Lindsay RileyDepartment of Biomedical Engineering, Duke University, Durham, NC 27705, USA.
Long NguyenDepartment of Biomedical Engineering, Duke University, Durham, NC 27705, USA.
Dimitris NtekoumesDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Sharon GerechtDepartment of Biomedical Engineering, Duke University, Durham, NC 27705, USA.
Tatiana SeguraDepartment of Biomedical Engineering, Duke University, Durham, NC 27705, USA; Clinical Science Departments of Neurology and Dermatology, Duke University, Durham NC 27710, United States.

Funding

VEGF Ligand Presentation and Therapeutic AngiogenesisR01NS079691 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SEGURA, TATIANA · 2012 to 2024
$4.0M
Biomaterials to promote synapse formation after strokeR01NS112940 · NINDS · DUKE UNIVERSITY · PI Tatiana Segura · 2020 to 2026
$3.9M
Engineering Adaptive Immune Responses from Hydrogel Scaffolds to Promote Tissue RegenerationR01AI152568 · NIAID · DUKE UNIVERSITY · PI COLLIER, JOEL H, SEGURA, TATIANA · 2020 to 2024
$3.2M
NIAID NIH HHS R01 AI152568NINDS NIH HHS R01 NS079691NINDS NIH HHS R01 NS112940
6 · The paper itself

Abstract

In tissues where the vasculature is either lacking or abnormal, biomaterials can be designed to promote vessel formation and enhance tissue repair. In this work, we independently tune the microstructure and bioactivity of microporous annealed particle (MAP) scaffolds to guide cell growth in 3D and promote de novo assembly of endothelial progenitor-like cells into vessels. We implement both

Indexed as

granularhydrogelmicrogelmicrostructureneovascularizationvasculogenesis

Identifiers

PMID41624796
PMCPMC12857857

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.