Evidence map›Paper›PMID 41624795›Full record

ArticleResearch (Washington, D.C.)2026

Epigenetic Suppression of RASAL1 by HDAC3 and Cofactor YY1 Promotes Fibroblast-Myofibroblast Transition and Renal Fibrosis.

Fang Chen, Lijun Zhang, Weiying Liu, Bingbing Zhang, Shuren Wang, Zhengdong Zhou, Wei Wang, Jiansong Shen, Yijun Deng, Wangsen Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fang ChenYancheng Key Laboratory of Molecular Epigenetics, Yancheng Medical Research Center of Nanjing University Medical School, The First People's Hospital of Yancheng, Yancheng 224006, China.
Lijun ZhangJiangsu Key Lab of Molecular Medicine, Nanjing University Medical School, Nanjing 210093, China.
Weiying LiuDepartment of Critical Care Medicine, The First People's Hospital of Yancheng, The Yancheng Clinical College of Xuzhou Medical University, Yancheng 224006, China.
Bingbing ZhangDepartment of Gastroenterology, The First People's Hospital of Shangqiu, Shangqiu 476005, China.
Shuren WangDepartment of Pathology, The First People's Hospital of Yancheng, The Yancheng Clinical College of Xuzhou Medical University, Yancheng 224006, China.
Zhengdong ZhouDepartment of Urology, The First People's Hospital of Yancheng, The Yancheng Clinical College of Xuzhou Medical University, Yancheng 224006, China.
Wei WangDepartment of Urology, The First People's Hospital of Yancheng, The Yancheng Clinical College of Xuzhou Medical University, Yancheng 224006, China.
Jiansong ShenDepartment of Nephrology, The First People's Hospital of Yancheng, The Yancheng Clinical College of Xuzhou Medical University, Yancheng 224006, China.
Yijun DengDepartment of Critical Care Medicine, The First People's Hospital of Yancheng, The Yancheng Clinical College of Xuzhou Medical University, Yancheng 224006, China.
Wangsen CaoYancheng Key Laboratory of Molecular Epigenetics, Yancheng Medical Research Center of Nanjing University Medical School, The First People's Hospital of Yancheng, Yancheng 224006, China.ORCID https://orcid.org/0000-0001-6209-3482

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibroblast-myofibroblast transition (FMT) and the resultant renal fibrosis are central pathological features of chronic kidney disease (CKD). Epigenetic suppression of RASAL1 (Ras protein activator like 1), an antifibrotic regulator in fibroblasts, is a key driver of this process. However, the underlying mechanisms are only partially understood. Here, we identify histone deacetylase 3 (HDAC3) as a critical epigenetic suppressor of RASAL1 expression in FMT of renal fibrosis. In mouse models of renal fibrosis induced by unilateral ureteral obstruction and aristolochic acid I, RASAL1 suppression coincided with a preferential increase in HDAC3. Fibroblast-specific

Identifiers

PMID41624795
PMCPMC12852569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.