ReviewFrontiers in molecular biosciences2025
Redox metabolism in cell senescence: focusing on contributions from the metabolomic field.
Review in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Glutathione Biology in Neurodegenerative and Metabolic Diseases: Molecular Mechanisms, Pathophysiological Roles, and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Plant-Derived Senotherapeutics in Cellular Senescence: A Scoping Review of Preclinical Evidence, Mechanistic Pathways, and Metabolomic-Guided Discovery.International journal of molecular sciences · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell senescence is triggered by stressful stimuli, including telomere attrition, genotoxic agents, and strong mitogenic signals. This state is characterized by proliferation arrest and acquisition of a senescence-associated secretory phenotype. Senescent cells secrete growth factors, chemokines, cytokines, proteases, and other factors that can impact the cell's microenvironment, promoting aging and the development of age-associated diseases. These discoveries have emphasized the need for a detailed analysis of the senescent phenotype. Redox alterations are one of the hallmarks of cellular senescence, and are required to maintain the senescent phenotype. Here, we review current information on senescent cell's redox metabolism, with a special focus on metabolomic profiling of human fibroblasts. We describe metabolic pathways involved in redox homeostasis, in particular glutathione metabolism, that undergo reprogramming in cell senescence, and links with the senescent phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.