ArticleCJC pediatric and congenital heart disease2025
Diastolic Function and Left Atrial Mechanics in Children With Marfan and Loeys-Dietz Syndrome.
Article in CJC pediatric and congenital heart disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Vascular and Ventricular Responses Assessed by Exercise Stress Echocardiography in Pediatric Marfan Syndrome.CJC pediatric and congenital heart disease · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Diastolic function in patients with pediatric Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS) remains underexplored. Conventional diastolic assessments in this population can be challenging, and speckle-tracking echocardiography (STE)-derived left atrial (LA) strain measurements offer a novel and sensitive approach. Methods: This retrospective, observational study included 37 patients with MFS, 37 patients with LDS, and 30 age-matched controls. Comprehensive echocardiographic evaluations were performed to assess diastolic function. STE-based LA strain measurements during the reservoir, conduit, and pump phases were obtained and analyzed. Results: Demographics were mostly similar between groups. Patients with MFS and LDS vs controls exhibited lower LA reservoir strain (42.3% vs 32.5% in MFS, Conclusions: Pediatric patients with MFS and LDS exhibit lower LA reservoir and conduit strains, along with differences in early diastolic parameters, while maintaining preserved LA pump function. These findings suggest subclinical changes in early diastolic function. STE-derived LA strain offers a sensitive, noninvasive method for detecting subtle functional impairments that may precede clinical dysfunction, underscoring its diagnostic potential for early monitoring and management of at-risk patients.
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