ArticleNeuroimage. Reports2026
Impact of SNAP-25 MnlI polymorphism on brain activity patterns in children with ADHD: Insights from fractional amplitude of low-frequency fluctuation analysis.
Article in Neuroimage. Reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: SNAP-25, a synaptic vesicle docking protein, carries a polymorphism (rs3746544) in its 3'-UTR region that is associated with ADHD, yet its functional mechanism remains unknown. The purpose of this study is to evaluate the impact of synaptosomal-associated protein 25 (SNAP-25) gene MnlI polymorphism (rs3746544) on spontaneous brain activity in children with attention deficit hyperactivity disorder (ADHD), employing the fractional amplitude of low-frequency fluctuation (fALFF) analysis of resting-state functional Magnetic Resonance Imaging (rs-fMRI) data, to explore its potential neurobiological mechanisms and neuroimaging biomarkers. Methods: This study enrolled 56 boys with ADHD (aged 8-10 years) and 21 age-matched healthy boys as healthy controls (HCs). According to the SNAP-25 MnlI genotype, ADHD patients were divided into two groups: the TT homozygote group (TT group, n = 36) and the G-allele carrier group (TG group, n = 20). Rs-fMRI data were acquired and analyzed using fALFF to measure spontaneous brain activity.One-sample Results: One-sample Conclusions: The SNAP-25 gene MnlI polymorphism has an impact on spontaneous brain activity in children with ADHD, as measured by fALFF. This study reveals the potential mechanisms from the perspective of brain networks, demonstrates how ADHD genotypes affect neural function, and provides a new approach for clinical decision-making and efficacy monitoring.
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