Evidence map›Paper›PMID 41624615›Full record

ArticleWorld journal of emergency medicine2026

Elevated serum osmolarity is associated with 28-day all-cause mortality in patients with cardiac arrest.

Ping Gong, Hong Zhao, Peijuan Li, Ling Wang, Jin Wang, Rui Yang, Zhangping Sun

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Article in World journal of emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ping Gong1Department of Emergency, Shenzhen People's Hospital (Second Clinical Medical College, Jinan University).
Hong Zhao2First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China.
Peijuan Li2Department of Emergency, Beijing Tongren Hospital, Capital Medical University, Beijing 100041, China.
Ling Wang3Health Management Center, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China.
Jin Wang1Department of Emergency, Shenzhen People's Hospital (Second Clinical Medical College, Jinan University).
Rui Yang1Department of Emergency, Shenzhen People's Hospital (Second Clinical Medical College, Jinan University).
Zhangping Sun4Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSerum osmolality is a prognostic indicator in critically ill patients. This study aimed to evaluate the association between high osmolality and 28-day mortality in patients with cardiac arrest (CA) admitted to the intensive care unit (ICU).

methodsBaseline data of adult patients with CA who were admitted to the ICU from 2008 to 2019 were collected from the Medical Information Mart for Intensive Care (MIMIC)-IV. Patients were divided into survivor and non-survivor groups according to the 28-day prognosis. Serum concentrations of sodium, potassium, glucose, and urea nitrogen on the first day of ICU admission were used to determine serum osmolarity. The primary endpoint of this study was 28-day all-cause mortality. Propensity score matching (PSM) analysis was performed to reduce bias between the survivor and non-survivor groups.

resultsAmong the 798 included CA patients, the high osmolarity on the first day of ICU admission remained significantly associated with increased 28-day mortality (62.0% vs. 35.5%,

conclusionIn this study, elevated serum osmolarity on the first day of ICU admission was independently associated with increased 28-day mortality in CA patients and could serve as a prognostic marker.

Indexed as

Cardiac arrestHigh osmolarityMortalitySerum osmolarity

Identifiers

PMID41624615
PMCPMC12856076

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.