Evidence map›Paper›PMID 41624539›Full record

ArticleMaterials today. Bio2026

Iron single-atom nanozyme-mediated laser interstitial thermal therapy and anti-inflammatory effect for epilepsy.

Xiao-Dan Zhang, Yu Tian, Jing Ma, Wei Lei, Wei-Jie Yu, Peng-Hui Liu, Wen Huang, Wei Huang, Ren-Fu Liu, Xiang-Tao Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiao-Dan ZhangDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Yu TianDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Jing MaDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Wei LeiDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Wei-Jie YuDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Peng-Hui LiuDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Wen HuangDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Wei HuangDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Ren-Fu LiuDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Xiang-Tao ZhangDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Feng WangDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Yang ZhuDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.
Yuan-Xiang LinDepartment of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Developing a safe and effective treatment for epilepsy (EP) necessitates a minimally invasive system capable of precisely targeting and ablating the lesion area while effectively suppressing subsequent inflammation. In this study, we present an innovative therapeutic strategy for epilepsy, leveraging iron single-atom nanozymes (Fe/SAN) in conjunction with laser interstitial thermal therapy (LITT) and their remarkable anti-inflammatory properties. This technology offers a significant advantage by enabling precise ablation of deep brain lesions and epileptic foci without the need for invasive craniotomy procedures. Notably, Fe/SAN exhibits exceptional near-infrared photothermal efficiency, which drives LITT to selectively eliminate diseased tissue. Moreover, near-infrared thermal imaging enables real-time monitoring of temperature changes in the epileptic lesion area, ensuring precise control of the therapeutic process. Additionally, Fe/SAN exhibits outstanding multienzyme-mimicking activities, which not only facilitate the precise ablation of epileptic foci but also scavenge reactive oxygen species and suppress inflammation. In kainic acid-induced epileptic mouse model, this combination effectively reduced seizure frequency and severity, improved spatial memory, and alleviated anxiety-like behaviors. This study introduces a novel "physical ablation-microenvironment regulation" strategy that achieves precise ablation of epileptic foci while modulating the local inflammatory microenvironment, thereby offering a highly promising minimally invasive treatment option for patients with drug-resistant epilepsy.

Indexed as

Anti-inflammatoryEpilepsyLaser interstitial thermal therapyReactive oxygen speciesSingle-atom nanozyme

Identifiers

PMID41624539
PMCPMC12858356

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.