Expanding the toolbox of bioorthogonal activation of photosensitizers for precise photodynamic therapy through transition metal-mediated deallylation.

Feijie Xu, Qianqian Wu, Lin He, Lin Yang, Pui-Chi Lo

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Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Feijie XuDepartment of Biomedical Sciences and Tung Biomedical Sciences Centre, College of Biomedicine, City University of Hong Kong, Kowloon, Hong Kong, China.

Qianqian WuDepartment of Biomedical Sciences and Tung Biomedical Sciences Centre, College of Biomedicine, City University of Hong Kong, Kowloon, Hong Kong, China.

Lin HeDepartment of Biomedical Sciences and Tung Biomedical Sciences Centre, College of Biomedicine, City University of Hong Kong, Kowloon, Hong Kong, China.

Lin YangDepartment of Biomedical Sciences and Tung Biomedical Sciences Centre, College of Biomedicine, City University of Hong Kong, Kowloon, Hong Kong, China.

Pui-Chi LoDepartment of Biomedical Sciences and Tung Biomedical Sciences Centre, College of Biomedicine, City University of Hong Kong, Kowloon, Hong Kong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The development of bioorthogonal activation of photosensitizers represents a promising avenue for precise photodynamic therapy (PDT) against cancer. It requires effective decaging strategies that can be applied in vivo, but such highly efficient and biocompatible methodologies remain scarce. We report herein the first use of ruthenium-mediated bioorthogonal deallylation for on-demand activation of boron dipyrromethene (BDP)-based photosensitizers. In this study, we first prepared a series of BDP-based photosensitizers connected to an allyl group with or without a self-immolative spacer via an ester caging unit [

Identifiers

PMID41624537

DOI10.1016/j.mtbio.2026.102797

PMCPMC12858366

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.