Evidence map›Paper›PMID 41624535›Full record

ArticleMaterials today. Bio2026

4D fabrication of scaffolds facilitates the construction of cholangiocyte monolayers from human and mouse liver derived organoids.

Junzhi Li, Shangsi Chen, Jing Chu, Yanghonghong Fei, Patrick Ho-Yu Chung, Kenneth Kak Yuen Wong, Vincent Chi Hang Lui, Paul Kwong Hang Tam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junzhi LiDepartment of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
Shangsi ChenDepartment of Biomedical Engineering, The Chinese University of Hong Kong, Sha Tin, New Territories, Hong Kong, China.
Jing ChuDepartment of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
Yanghonghong FeiDepartment of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
Patrick Ho-Yu ChungDepartment of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
Kenneth Kak Yuen WongDepartment of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
Vincent Chi Hang LuiDepartment of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.
Paul Kwong Hang TamDepartment of Surgery, School of Clinical Medicine, The University of Hong Kong, Hong Kong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blockage and absence of bile ducts lead to liver defects, highlighting the urgent need for effective regenerative solutions. Tissue engineering has emerged as an interdisciplinary solution for repairing and regenerating damaged bile duct tissue. However, challenges such as achieving good organoid viability and morphological remodeling within scaffolds remain. In this study, surface-modified biodegradable shape memory (SMP) scaffolds were designed and fabricated to construct cell-laden 3D bile duct tubes using both human and mouse liver derived cholangiocyte organoids as cell sources. The SMP scaffolds demonstrate superb biocompatibility and good shape memory properties, which support organoid attachment and integration, enhancing cholangiocytes proliferation and monolayer formation. Our cell-laden SMP scaffolds facilitated the

Indexed as

4D cholangiocyte monolayerBile duct tissue engineeringCholangiocyte organoidsShape memory polymer scaffolds

Identifiers

PMID41624535
PMCPMC12857267

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.