Escape from cell uptake: Drug-Free cancer therapeutics regulated by hydrophobicity and negative charge.

Kazuki Moroishi, Masahiko Nakamoto, Satoshi Fujita, Marie Kawahara, Ryohei Katayama, Michiya Matsusaki

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kazuki MoroishiDivision of Applied Chemistry, Graduate School of Engineering, The University of Osaka, Osaka, Japan.

Masahiko NakamotoDivision of Applied Chemistry, Graduate School of Engineering, The University of Osaka, Osaka, Japan.

Satoshi FujitaAdvanced Photonics and Biosensing Open Innovation Laboratory, National Institute of Advanced Industrial Science and Technology, P3 Bldg., Photonics Center, Osaka University2-1 Yamada-Oka, Suita, Osaka 565-0871, Japan.

Marie KawaharaThe Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.

Ryohei KatayamaThe Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.

Michiya MatsusakiDivision of Applied Chemistry, Graduate School of Engineering, The University of Osaka, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-aggregation and inducing cell membrane disruption in response to tumor microenvironment-stimuli is expected to be a promising approach for cancer treatment, but is limited by its insufficient stimuli-responsive cytotoxicity due to a lack of in-depth understanding of molecular characteristics, resulting in low selectivity of cell death induction. In this study, we focused on engineering polymer aggregation in detail to further improve tumor microenvironment-responsive cytotoxicity. PVA-U with grafting degrees (G.D.) of 3 % (PVA-U3), 15 % (PVA-U15), and 25 % (PVA-U25) were synthesized and their aggregation properties cytotoxicity was evaluated. The difference in half maximal inhibitory concentration (IC

Indexed as

Cancer therapyDrug delivery systempH-responsive aggregation

Identifiers

PMID41624522

DOI10.1016/j.mtbio.2025.102752

PMCPMC12857268

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.