Evidence map›Paper›PMID 41624403›Full record

ArticleMolecular therapy. Oncology2026

Virus-based IFNγ gene delivery and photodynamic therapy cooperate to remodel the tumor microenvironment and suppress breast cancer.

Ksenija Korotkaja, Zhanna Rudevica, Darija Lapina, Dace Skrastina, Juris Jansons, Olga Nilova, Karina Spunde, Anna Zajakina

Abstract read
In one paragraph

Article in Molecular therapy. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ksenija KorotkajaLatvian Biomedical Research and Study Centre, Ratsupites Str. 1, k.1, 1067 Riga, Latvia.
Zhanna RudevicaLatvian Biomedical Research and Study Centre, Ratsupites Str. 1, k.1, 1067 Riga, Latvia.
Darija LapinaLatvian Biomedical Research and Study Centre, Ratsupites Str. 1, k.1, 1067 Riga, Latvia.
Dace SkrastinaLatvian Biomedical Research and Study Centre, Ratsupites Str. 1, k.1, 1067 Riga, Latvia.
Juris JansonsLatvian Biomedical Research and Study Centre, Ratsupites Str. 1, k.1, 1067 Riga, Latvia.
Olga NilovaLatvian Biomedical Research and Study Centre, Ratsupites Str. 1, k.1, 1067 Riga, Latvia.
Karina SpundeLatvian Biomedical Research and Study Centre, Ratsupites Str. 1, k.1, 1067 Riga, Latvia.
Anna ZajakinaLatvian Biomedical Research and Study Centre, Ratsupites Str. 1, k.1, 1067 Riga, Latvia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study demonstrates a potent synergistic anti-tumor effect of photodynamic therapy (PDT) based on chlorin e6 (Ce6) combined with Semliki Forest virus-mediated IFNγ (SFV/IFNγ) delivery in 4T1 mouse breast cancer model. We demonstrate that Ce6-PDT promotes macrophage-mediated phagocytosis of cancer cells but fails to reprogram macrophages into an M1-like phenotype.

Indexed as

alphaviruscancer gene therapychlorin e6interferon gammamacrophage reprogrammingMT: Regular Issuephotodynamic therapyspheroid modelvirus vector

Identifiers

PMID41624403
PMCPMC12857546

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.