ArticleJournal of undergraduate chemistry research2025
BIOCHEMICAL INVESTIGATION OF THE ANTICOAGULANT ACTIVITY OF SULFONATED POLYMERS.
Article in Journal of undergraduate chemistry research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Fully Synthetic Non-Carbohydrate Heparin Mimetics-Perspectives for Therapeutic Anticoagulation and Beyond?Archiv der Pharmazie · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Venous thrombotic disorders are a leading cause of mortality in the US. While anticoagulants are the primary treatment, their use is limited by bleeding risks. This highlights the critical need for safer alternatives. In this study, we investigated eight sulfonated polymers for anticoagulant potential using human plasma clotting assays. Nonacetylated lignosulfonate (NALS) emerged as the most promising candidate, doubling clotting times at 309-980 μg/mL concentrations. We also performed chromogenic assays targeting key coagulation factors (thrombin, factor Xa, and factor XIa) to elucidate its mechanism of action. NALS exhibited a potent and selective inhibition of factor XIa, with an IC
Indexed as
Identifiers
41624402PMC12857833What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.