Observational studyMediators of inflammation2026
Phenotypic Heterogeneity in Glaucoma: The Systemic and Vascular Landscape Behind Functional Loss.
Observational study in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Prognostic value of applanation tonometry, pachymetry and automated perimetry in monitoring glaucoma progression: A longitudinal analytical study.Bioinformation · 2026Article
- Phenotypic Heterogeneity in Glaucoma: The Systemic and Vascular Landscape Behind Functional Loss.Mediators of inflammation · 2026Observational
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To analyze the direct and indirect associations between structural, functional, and systemic variables in patients with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), and controls using structural equation modeling (SEM). Methods: A cross-sectional observational study was conducted including 156 participants: 55 with POAG, 49 with NTG, and 52 age- and sex-matched controls. Clinical variables included intraocular pressure (IOP), central corneal thickness (CCT), vertical cup-to-disc ratio (VCDR), and visual-field mean deviation (MD). Systemic variables comprised age and cardiovascular risk factors (hypertension, diabetes, and dyslipidemia). SEM was applied to assess direct and indirect effects on the diagnosis of glaucoma. Results: The model showed a good overall fit ( Conclusions: Our findings support the hypothesis of distinct glaucomatous phenotypes, including a vascular subtype with lower IOP and altered perfusion, potentially influenced by systemic comorbidities and chronic treatments. Reduced CCT was also confirmed as an independent marker of advanced functional loss. SEM helps disentangle complex mechanisms and may inform personalized therapeutic strategies, particularly in NTG.
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Registered trials
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