ArticleInternational journal of clinical pediatric dentistry2026
Effect of Baicalein on Odontogenic Differentiation of Dental Pulp Stem Cells: An
Article in International journal of clinical pediatric dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Human dental pulp cells (HDPCs) are the primary cellular components of the pulp tissue and play a crucial role in its regenerative potential. In the context of vital pulp therapy (VPT), naturally derived herbal compounds have emerged as potential alternatives to conventional direct pulp capping agents due to their biocompatibility and bioactivity. Baicalein, a flavonoid derived from Aim: To evaluate the effect of baicalein on the odontogenic differentiation of DPSCs. Materials and methods: Baicalein was prepared in varying concentrations from a commercially available source. DPSCs were isolated using the explant culture method and characterized through flow cytometry for mesenchymal stem cell (MSC) markers: CD73, CD90 (positive), and CD34, CD45, and HLA-DR (negative). Cytotoxicity was assessed using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. Odontogenic differentiation and mineralization were evaluated by measuring alkaline phosphatase (ALP) activity and mineral deposition using 2% Alizarin Red S staining. Results: Mesenchymal stem cells from explant culture were free of hematopoietic lineage. MTT assay showed no cytotoxicity at 1-50 µg/mL. Compared to control, 10 and 15 µg/mL baicalein increased cell proliferation, though higher concentrations reduced it. At 10 µg baicalein, ALP activity ( Conclusion: Baicalein promotes odontogenic differentiation and mineralization of DPSCs at optimal concentrations, highlighting its potential as a novel bioactive agent in direct pulp capping procedures. How to cite this article: Patil S, Pawar M, Kharat A,
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