ArticleSmall science2026
Targeted Nanocomplex Delivery for Protecting Vascular Integrity and Enhancing Anticancer Effects in Hepatocellular Carcinoma.
Article in Small science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Focused ultrasound for cellular mechanoactivation and nanomedicine delivery in cancer.Biomedical microdevices · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In cancer treatment, it is critical to enhance drug delivery efficiency to the target area while minimizing the side effects of chemotherapeutic drugs. Although intravenous administration of anticancer agents is commonly used, it often results in blood vessel damage and systemic side effects as well as poor targeted delivery. Therefore, developing new drug delivery formulations is essential to improve anticancer efficacy while reducing side effects. Herein, a nanohybrid methodology is presented to improve the targeted delivery of doxorubicin (DOX) for treating hepatocellular carcinoma (HCC) and to minimize vascular damage. An albumin-glucosamine (AG) lipid complex (LC), composed of stearyl glycyrrhetinate (SG) and DSPE-PEG, is designed to serve as a liver cancer-specific delivery system. The nanohybrid formulation, SGLC/DOX@AG, demonstrates significant anticancer activity and reduced side effects, as demonstrated by in vitro, in vivo, and cancer-on-a-chip models. This study presents a novel carrier design and application model for drug formulation development and efficacy validation, providing insights into therapeutic development for HCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.