Evidence map›Paper›PMID 41624260›Full record

ArticleObstetrics and gynecology international2026

Different Expressions and Methylation Patterns of cGAS and STING in Cervical Cancer.

Ruimin Wang, Shuling Liu, Rui Wang, Quanquan Guo, Xiaoyuan Lu

Abstract read
In one paragraph

Article in Obstetrics and gynecology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruimin WangDepartment of Obstetrics and Gynecology, Suqian Affiliated Hospital of Xuzhou Medical University, No. 138 Huanghe Road, Suqian City, 223806, China.
Shuling LiuDepartment of Oncology, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, China, sumhs.edu.cn.
Rui WangDepartment of Oncology, Suqian Affiliated Hospital of Xuzhou Medical University, No. 138 Huanghe Road, Suqian City, 223806, China.ORCID https://orcid.org/0000-0003-0773-2127
Quanquan GuoDepartment of Hematology, the Second Affiliated Hospital of Soochow University, No. 1055 San Xiang Road, Su Zhou City, 215004, China, suda.edu.cn.ORCID https://orcid.org/0000-0002-9563-9952
Xiaoyuan LuDepartment of Obstetrics and Gynecology, the Affiliated Hospital of Xuzhou Medical University, Xuzhou, 221002, China, xzmc.edu.cn.ORCID https://orcid.org/0009-0002-4265-8401

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The cGAS-STING pathway has established itself as a critical innate immune pathway that has the ability to significantly affect tumor initiation and progression. The expression, methylation, immunological functions, and prognostic importance of cGAS-STING pathway-related genes in cervical squamous cancer (CESC) patients have not yet been thoroughly elucidated. Methods: First, we explored the expression of cGAS and STING in cervical carcinoma samples from TCGA by comparing the mRNA and protein levels of cGAS and STING in both TCGA cervical tumor patient samples and cervical tumor cell lines. Second, we examined the CD4 Results: In both cervical tumor patient samples and cell lines, we observed that cGAS is increased, whereas STING is decreased in tumors, which leads to decreased CD4 Conclusions: Our work identified different expressions and methylation patterns of cGAS and STING in cervical cancer and their correlation with immune T cell infiltration and prognosis. More mechanistic study is needed to understand the cGAS-STING pathway in cervical squamous tumor.

Indexed as

cervical tumorcGASmethylationSTINGTCGA

Identifiers

PMID41624260
PMCPMC12858420

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.