Evidence map›Paper›PMID 41624247›Full record

ArticleOsteoarthritis and cartilage open2026

Association between symptomatic knee osteoarthritis and health-related quality of life in individuals with type 2 diabetes: A cross-sectional study.

Abdalmohsen Almodahka, Alanna Weisman, Baiju R Shah, Tristan Watson, Ian Stanaitis, Amish Parikh, Robert Goldberg, Lorraine Lipscombe, Gillian A Hawker, Lauren K King

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Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Abdalmohsen AlmodahkaDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Alanna WeismanDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Baiju R ShahDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Tristan WatsonInstitute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Ian StanaitisResearch and Innovation Institute, Women's College Hospital, Toronto, ON, Canada.
Amish ParikhDivision of Endocrinology, Department of Medicine, Trillium Health Partners, Mississauga, ON, Canada.
Robert GoldbergDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Lorraine LipscombeDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Gillian A HawkerDepartment of Medicine, University of Toronto, Toronto, ON, Canada.
Lauren K KingDepartment of Medicine, University of Toronto, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Knee osteoarthritis (OA) and type 2 diabetes (T2D) commonly coexist, but their combined impact on health-related quality of life (HRQoL) remains understudied. We assessed the association between symptomatic knee OA and HRQoL in individuals with T2D and explored potential explanations. Design: We conducted a secondary analysis of a cross-sectional study of individuals with T2D. Symptomatic knee OA was defined using NICE criteria (age ≥45 years, activity-related knee pain, morning stiffness ≤30 min; no inflammatory arthritis). HRQoL (EQ-VAS, 0-100), sleep disturbance (PROMIS Sleep Disturbance 4a), depressed symptoms (PROMIS Depression 8b), fatigue (PROMIS Fatigue 4a), and walking limitation (Health Assessment Questionnaire) were assessed via questionnaire. Linear regression modeled associations between knee OA and HRQoL, adjusting for age, gender, BMI, education, and comorbidities. The explanatory effects of sleep, mood, and mobility were assessed via further sequential adjustment. Results: We included 341 participants: mean age 66.4 years, 51.9 % female, 29.0 % had knee OA. Participants with T2D and knee OA reported lower HRQoL, greater sleep disturbance, fatigue, depressive symptoms, and walking limitations than those without knee OA. Knee OA was associated with lower HRQoL (β = -11.96; 95 % CI: -16.59 to -7.32) in the unadjusted analysis. Adjustment for confounders partially attenuated this effect (β = -8.33; 95 % CI: -12.72 to -3.94). Further adjustment for sleep, mood, and walking limitations fully attenuated the association. Conclusion: Symptomatic knee OA is strongly associated with impaired HRQoL in T2D, explained by sleep disturbance, low mood, and mobility limitation. Integrated care addressing OA may improve quality of life in this population.

Indexed as

DepressionKnee osteoarthritisMobility limitationQuality of lifeSleep disturbanceType 2 diabetes mellitus

Identifiers

PMID41624247
PMCPMC12857330

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.