ArticleFrontiers in nutrition2025
Body composition shapes cardiometabolic risk in children with multifactorial dyslipidemia.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Childhood-onset multifactorial dyslipidemia is associated with obesity and early cardiometabolic risk, yet weight status alone may not reflect abnormalities in body composition. We aimed to examine associations between body composition, physical activity, and cardiometabolic markers in this population. Methods: This observational study included 101 children (mean age 13.8 ± 3.2 years) referred to a tertiary lipid clinic. Body composition was assessed by bioelectrical impedance analysis. Individuals were stratified by fat mass z-score (<2 vs. ≥2) to compare clinical characteristics. Cardiometabolic markers included blood pressure percentiles, the homeostasis model assessment of insulin resistance (HOMA-IR), and the triglyceride-to-high-density lipoprotein cholesterol (HDL-C) ratio. Results: Most participants (67%) had obesity, high fat mass (median z-score 3.51), low muscle-to-fat ratio (z-score-1.62), and low physical activity (2 h/week). Those with fat mass z-scores ≥2 had higher blood pressure percentiles, triglycerides, HOMA-IR, and triglyceride-to-HDL-C ratios, and lower muscle-to-fat ratios (all Discussion: In pediatric multifactorial dyslipidemia, both adiposity and muscle-to-fat imbalance contribute to early cardiometabolic risk and may improve risk stratification.
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