ArticleFrontiers in neuroscience2025
Immune-derived cardiac autonomic signatures: predicting autonomic responses to exercise from B-cell phenotypes.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- CD21Frontiers in aging · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Aging affects both immune and autonomic regulation, yet their interaction remains poorly characterized. This study investigated how aging B-cell subpopulations, defined by CD21/CD11c expression, are associated with autonomic nervous system (ANS) dynamics, as measured by heart rate variability (HRV) during exercise in older adults. Materials and methods: In this cross-sectional study, 81 community-dwelling older adults (mean age 70.7 ± 5.8 years) underwent immune flow cytometry profiling of total B cells and four CD21/CD11c phenotypes. Continuous R-R interval (RRi) data were recorded at rest, during a standardized Two-Minute Step Test (TMST), and over a 5-min recovery period. A coupled-logistic RRi-vs-time model capturing each participant's cardiac autonomic signature (CAS) was obtained. Individual parameter estimates were regressed on standardized immune predictors using multivariate Bayesian models adjusted for age, sex and body composition. Results: Higher counts of CD21 Conclusion: CD21
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