Evidence map›Paper›PMID 41624138›Full record

ArticleFrontiers in neuroscience2025

Peripheral and central auditory dysfunction, cardiometabolic multimorbidity, and cognitive performance in community-dwelling older adults: a cross-sectional study.

Jian Ruan, Xiuhua Hu, Min Zhang, Weibin Zhang, Yan Zhang, Zhao Han, Jie Chen, Qingwei Ruan, Jingchun He, Bing Chen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jian RuanDepartment of Otorhinolaryngology Head and Neck Surgery, Huadong Hospital Affiliated with Fudan University, Shanghai, China.
Xiuhua HuShanghai Key Laboratory of Clinical Geriatrics, Shanghai Institute of Geriatrics and Gerontology, Huadong Hospital Affiliated with Shanghai Medical College, Fudan University, Shanghai, China.
Min ZhangShanghai Key Laboratory of Clinical Geriatrics, Shanghai Institute of Geriatrics and Gerontology, Huadong Hospital Affiliated with Shanghai Medical College, Fudan University, Shanghai, China.
Weibin ZhangShanghai Key Laboratory of Clinical Geriatrics, Shanghai Institute of Geriatrics and Gerontology, Huadong Hospital Affiliated with Shanghai Medical College, Fudan University, Shanghai, China.
Yan ZhangDepartment of Geriatrics, Huadong Hospital Affiliated with Fudan University, Shanghai, China.
Zhao HanDepartment of Otorhinolaryngology Head and Neck Surgery, Huadong Hospital Affiliated with Fudan University, Shanghai, China.
Jie ChenShanghai Key Laboratory of Clinical Geriatrics, Shanghai Institute of Geriatrics and Gerontology, Huadong Hospital Affiliated with Shanghai Medical College, Fudan University, Shanghai, China.
Qingwei RuanShanghai Key Laboratory of Clinical Geriatrics, Shanghai Institute of Geriatrics and Gerontology, Huadong Hospital Affiliated with Shanghai Medical College, Fudan University, Shanghai, China.
Jingchun HeDepartment of Otorhinolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Bing ChenState Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Department of Otorhinolaryngology, Eye & ENT Hospital, ENT Institute, Fudan University, Shanghai, China.
Zhijun BaoShanghai Key Laboratory of Clinical Geriatrics, Shanghai Institute of Geriatrics and Gerontology, Huadong Hospital Affiliated with Shanghai Medical College, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Both age-related peripheral or central hearing loss, and cardiometabolic multimorbidity (CMM), which are independent association with global and domain-specific cognitive impairment, are common among older adults. Cardiometabolic diseases also are independent risk factors of age-related hearing loss. The first aim of the study was to investigate the independent and joint influence of CMM and low- and high-frequency hearing loss or central auditory processing dysfunction (CAPD) on global and domain-specific cognitive impairment. The second aim was to investigate whether CMM mediate the effects of age-related hearing loss on cognitive performance. Methods: In total, 508 eligible community-dwelling dementia-free older adult participants agreed to participate and completed a cross-sectional investigation. The averages of thresholds at 0.5, 1, and 2 kHz for low frequency (LPTA) and at 4, 6, and 8 kHz for high frequency (HPTA) were calculated. CAPD was assessed using SNR (signal-to-noise ratio threshold) in a words-in-noise test. Global and domain-specific cognitive performance was measured using a comprehensive neuropsychological test battery. This study analyzed the independent associations between LPTA, HPTA, CAPD, or CMM and global and domain-specific cognitive performance after adjusting for each other and other confounders. Weighted logistic regression were used to assess the joint effects of CMM and the LPTA, HPTA, or CAPD on cognitive performance. The R package "Mediation" was used to examine whether CMM mediated the associations between LPTA, HPTA, or CAPD and cognitive performance. Results: CMM was independently associated with global cognitive performance in pre-MCI [ Conclusion: CMM and CAPD were significantly associated with global cognition. CMM and HPTA were significantly associated executive function in the sensitivity test. CMM, and LPTA, HPTA, or CAPD had jointly effects on global cognition. CMM and HPTA had significant joint effect on executive function. CMM might mediate the association between the HPTA and global or executive function in individuals with LPTA ≤ 40 dB HL. These findings indicated that an integrated interventional approach for presbycusis and CMM simultaneously may delay cognitive decline in older adults.

Indexed as

age-related hearing losscardiometabolic multimorbiditycentral auditory processingcognitive impairmenthigh-frequency hearing losslow-frequency hearing loss

Identifiers

PMID41624138
PMCPMC12856757

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.