ArticleFrontiers in neuroscience2025
Association between post-traumatic stress disorder levels and serum inflammatory factors in patients undergoing digit replantation.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Psychological outcomes following digital replantation and revascularization: A narrative review.Journal of hand and microsurgery · 2026Review
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7 authors.
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Abstract
Objective: To investigate the levels of early postoperative post-traumatic stress disorder (PTSD) and their association with serum inflammatory factors in patients undergoing digit replantation, and to analyze the influencing factors. Methods: A total of 96 patients who underwent digit replantation at Rizhao People's Hospital between March 2022 and December 2024 were enrolled 7 days postoperatively. PTSD levels were assessed using the PTSD Checklist-Civilian Version (PCL-C). Morning fasting blood samples were collected, and serum levels of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and IL-10 were measured by ELISA. Data were analyzed using univariate analysis, Spearman's correlation, multiple linear regression, and Receiver Operating Characteristic (ROC) curve analysis. Results: The mean PCL-C score for the 96 patients was 38.21 ± 9.31, with 44 patients (45.83%) presenting PTSD symptoms. Univariate analysis revealed that gender, education level, injury type, complete amputation, involvement of the dominant hand, and number of amputated digits significantly influenced PCL-C scores ( Conclusion: Patients exhibit a certain degree of PTSD in the early stage after digit replantation. Its occurrence is closely associated with female gender, lower education level, severity of the trauma, and co-morbid anxiety and depression, and is significantly correlated with an imbalance between pro-inflammatory and anti-inflammatory serum factors. Serum inflammatory factors may serve as potential biological markers for the early identification of PTSD risk.
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