ArticleFrontiers in public health2026
Pathogen profiles and risk factors of hospital-acquired infections in traumatic brain injury patients.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Traumatic brain injury (TBI) represents a significant public health challenge, marked by elevated incidence rates and significant morbidity, frequently resulting in long-term disabilities and imposing substantial economic burdens on healthcare systems. This study seeks to examine the incidence of hospital-acquired infections (HAIs), characterize prevalent pathogens, evaluate antimicrobial susceptibility patterns, and identify risk factors associated with HAIs in TBI patients. Methods: A retrospective analysis was performed on a cohort of 2,314 hospitalized TBI patients. Data were collected on demographic characteristics, clinical history, treatment modalities, and infection outcomes were systematically collected. The incidence proportion of HAIs in TBI patients was analyzed, key pathogens and their antimicrobial resistance patterns were identified. Univariate and multivariate logistic regression analyses were performed to assess risk factors for HAIs of TBI patients. Results: Among 2,314 hospitalized TBI patients, the incidence of HAIs was 19.40%. The most frequent infection sites were the lower respiratory tract (14.87%) and urinary tract (6.66%), whereas gentral nervous system infections were infrequent (0.39%). A total of 555 distinct pathogens were first-isolated, with Gram-negative bacteria representing the majority (66.85%), particularly Conclusion: This study highlights the necessity of risk factor identification for HAIs to facilitate risk stratification and the implementation of targeted preventive measures in the clinical management of TBI patients. Furthermore, sustained microbial surveillance is imperative to guide antibiotic stewardship and enhance diagnostic and therapeutic strategies for this patient population.
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