Evidence map›Paper›PMID 41624074›Full record

ArticleRegenerative therapy2026

A thermo-responsive sol-to-gel phase transition hydrogel for sustained delivery of mesenchymal stem cell-derived exosomes.

Lefeng Liu, Lijuan Yang, Zhiguo Xu, Zhilong Dong, Ze Xu, Shaorong Gao, Xiaoyu Liu, Yong Kong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lefeng LiuSchool of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Lijuan YangZhejiang South Taihu Precision Medicine Co., Ltd., Huzhou, 313000, China.
Zhiguo XuSchool of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Zhilong DongState Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Sciences and College of Life Sciences, Nankai University, Tianjin, 300071, China.
Ze XuJiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, 213164, China.
Shaorong GaoSchool of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Xiaoyu LiuSchool of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.
Yong KongJiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, 213164, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Mesenchymal stem cells-derived exosomes (MSC-Exo) have significant therapeutic potential in regenerative medicine but face challenges such as rapid systemic clearance and poor retention at target sites. In this study, a thermo-responsive sol-to-gel phase transition hydrogel based on sodium alginate (SA), cellulose nanofibrils (CNF) and poloxamer 407 (P407) was prepared for sustained delivery of MSC-Exo. Methods: The MSC-Exo loaded CNF/SA hydrogel was prepared, which was freeze-dried and then dispersed in the P407 solution at room temperature. The mixture of CNF/SA/MSC-Exo and P407 could undergo thermo-responsive sol-to-gel phase transition due to the thermosensitive property of P407, and thus the CNF/SA/MSC-Exo was encapsulated in the P407 gel at physiological temperature (37 °C). Results: Owing to the high degradation ratio of P404 gel and swelling ratio of CNF/SA hydrogel at physiological pH (∼7.4), sustained delivery of MSC-Exo from the gel was achieved with a high cumulative release of 80 % after 120 h. Cytotoxicity assay showed that the CNF/SA/P407 gel has excellent biocompatibility. Conclusions: These findings provide a feasible strategy to achieve the sustained delivery of Exo for regeneration therapy, giving valuable references for future research.

Indexed as

Mesenchymal stem cells-derived exosomesNatural polysaccharidesPhase transitionSustained deliveryThermoresponsive polymers

Identifiers

PMID41624074
PMCPMC12859757

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.