ArticleRegenerative engineering and translational medicine2025
Niclosamide-Loaded Polyanhydride Nanoparticles to Combat Gemcitabine Resistance in Pancreatic Cancer.
Article in Regenerative engineering and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
12 authors.
Funding
Abstract
Purpose: Pancreatic cancer (PC) is a highly lethal malignancy and lacks effective treatments. Current chemotherapies, including gemcitabine (Gem) in combination treatment regimens, produce dose-limiting toxicity, drug resistance, and ultimately limited improvement in the overall survival of PC patients. Niclosamide (Nic), a clinically safe FDA-approved anthelmintic drug has been shown to have anti-cancer properties; however, its limited bioavailability makes Nic largely ineffective as a therapeutic agent. To address this challenge, we have developed a novel combination therapy of Gem with the repurposed drug, Nic, loaded in biodegradable polyanhydride nanoparticles (NicNp), as an effective treatment option for PC. Methods: We synthesized and characterized NicNp in vitro and evaluated their biodistribution and efficacy in xenograft and syngeneic pancreatic tumor models in mice. Results: The biodistribution study indicated that NicNp accumulated in high concentrations in the pancreatic tumors of the mice with C Conclusions: This study demonstrates the potential for effective repurposing Nic via nanoformulations in combination with Gem to improve PC treatment efficacy. Lay summary: Pancreatic cancer (PC) ranks among the most lethal types of cancer, with largely ineffective current treatments and toxic side effects in patients. Niclosamide is an FDA-approved anti-parasitic drug with minimal side effects, that has shown some anti-cancer properties. However, it is not effectively absorbed in the body. We produced polymer nanoparticles to deliver niclosamide effectively to treat pancreatic tumors in mice in combination with the chemotherapeutic gemcitabine. This combination treatment led to PC tumor reduction and increased the survival, demonstrating that niclosamide encapsulated in nanoparticles in combination with gemcitabine has the potential to be a more effective treatment for PC. Graphical Abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s40883-025-00394-0.
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