ArticleRegenerative engineering and translational medicine2025
Safety and Biocompatibility of a Spray-Dried Influenza Microparticle Vaccine in Mice.
Article in Regenerative engineering and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Abstract: Influenza virus is a persistent source of morbidity and moribundity, and effective disease control requires ever-evolving effective vaccines. In this work, we evaluate the safety and biocompatibility of two novel polymeric particle-based influenza vaccines. Mice were immunized either intranasally or subcutaneously with these two formulations and examined at 1 h, 1 day, and 14 days post-immunization for histopathology in liver, kidneys, and lungs and serum biomarker analysis. Mice that received an intranasal vaccination were also observed for pulmonary disruption via whole body plethysmography. Examination of tissues post-immunization found only limited inflammation, with no difference observed in plethysmography measurements and no serum biomarkers (e.g., AST, AlkPhos) indicating tissue damage. Collectively, these data support the conclusion that these polymeric particle-based influenza vaccine formulations were well tolerated by the animals and did not induce any adverse side effects. Lay summary: Particle-based influenza vaccines were safety tolerated by mice and did not induce any adverse side effects. Supplementary Information: The online version contains supplementary material available at 10.1007/s40883-025-00473-2.
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