ReviewRegenerative engineering and translational medicine2025
Hydrogel Design to Understand and Guide 3D Cell Migration.
Review in Regenerative engineering and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Cell homing within endodontic hydrogels: A scoping review.The Japanese dental science review · 2026Review
- Matrix degradation promotes fibronectin deposition and spatial remodeling in 3D.Cell reports. Physical science · 2026Article
- Guiding of Cell Migration over Sloped Steps Using TiOJournal of functional biomaterials · 2026Article
- Dynamic Regulation of Granular Hydrogels Through Guest-Host Interactions to Spatiotemporally Guide Cellular Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Purpose: The extracellular environment is critical for cell migration in three-dimensions (3D), which has been understudied when compared to cell migration on two-dimensional (2D) substrates. In 3D, cells must degrade or remodel their surroundings to overcome barriers to migration or find paths that act as migration routes. Methods: We performed a literature search for studies related to the engineering of hydrogels to understand and control cell migration. Results: This review highlights the cell-intrinsic machinery that is required for migration, describes how cell migration can be modeled in vitro, and provides examples where hydrogels have been designed with permissive extracellular cues that enhance cell migration for biomedical applications. Conclusions: Hydrogels can be engineered to mimic many features of the extracellular space to help us better understand the interplay between cells and their environment and interpret how these complex processes support or limit cell migration. With this understanding, hydrogels can be designed to guide cellular migration, particularly in the context of tissue repair and regenerative medicine. Lay Summary: Cell movement is important in both healthy and diseased tissues. An understanding of how cells migrate and the development of methods to control their migration can be utilized to improve patient therapies in the future in applications such as tissue repair and regeneration. Hydrogels are water-swollen materials that mimic many features of tissues. This allows their use to understand how cells respond to various features in their environment, as well as for therapeutic materials in tissue repair. This review highlights advances on these topics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.