ArticleLiver cancer2025
Utility of Biomarker Panels in the Surveillance and Monitoring of Hepatocellular Carcinoma: Consensus Statements from an International Delphi Panel.
Article in Liver cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Risk Assessment and Prediction of Hepatocellular Carcinoma in Noncirrhotic Metabolic Dysfunction-Associated Steatotic Liver Disease.International journal of molecular sciences · 2026Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatocellular carcinoma (HCC) surveillance is recommended using a combination of abdominal ultrasound plus alpha-fetoprotein (AFP) in patients with chronic hepatitis B or cirrhosis from any etiology. However, this strategy is limited by suboptimal sensitivity for early-stage HCC, particularly in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and alcohol-associated liver disease. Phase 2 and phase 3 biomarker studies have reported the promise of novel blood-based biomarkers, including AFP, des-gamma-carboxy prothrombin, and lens culinaris agglutinin-reactive AFP (AFP-L3). Biomarker panels, such as the GALAD score, GAAD, and ASAP combine these biomarkers plus age and gender into biomarker panels. A panel of 10 experts from Asia and the USA convened to discuss the clinical utility of these biomarkers for detecting early-stage HCC. The experts agreed that biomarker panels have shown higher sensitivity than each individual biomarker and showed promise for early-stage HCC detection, particularly in those with a high proportion of patients with obesity and MASLD and geographies with insufficient access to high-quality ultrasound. However, biomarkers require prospective validation in clinical utility trials demonstrating net benefit in patients with cirrhosis, and implementation may face challenges including widespread access to testing, broader insurance coverage, and improving awareness among physicians and patients.
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