ArticlebioRxiv : the preprint server for biology2026
3'-tRNA Fragments Target Domesticated LTR-Retrotransposons.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
Abstract
Long terminal repeat (LTR) retrotransposons have been extensively co-opted by their mammalian hosts and serve essential functions. 3'-tRNA fragments (3'-tRFs) mediate post-transcriptional repression of active, murine LTR-retrotransposons through complementarity to their highly conserved tRNA primer binding site (PBS). Here, we found that 3'-tRF target sites derived from the PBS are widespread in retrotransposon-derived transcripts, suggesting that domesticated elements remain subject to regulation. Using luciferase reporters, we validated post-transcriptional repression at multiple 5' UTR sites derived from LTR-retrotransposons. We further established paternally expressed 3 (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.