Case Report: Post-transplant lymphoproliferative disorder after kidney transplantation in a child with schimke immuno-osseous dysplasia.

Peng Liu, Xiyan Tian, Daokui Ding, Lei Wang, Peile Wang

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Peng LiuDepartment of Pediatric Intensive Care Unit, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Xiyan TianDepartment of Pediatric Intensive Care Unit, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Daokui DingDepartment of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Lei WangDepartment of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Peile WangDepartment of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the inherent T-cell immunodeficiency of Schimke immune-osseous dysplasia (SIOD), the management of immunosuppressive therapy after transplantation and life-threatening infections remains a challenge. Here, we present a case of a child with SIOD who developed early-onset Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD) after kidney transplantation. PTLD frequently involves the gastrointestinal tract and solid allografts, while this case also involved the lungs, which is extremely rare. This case underscores the importance of considering PTLD in recipients with immunodeficiency, long-term immunosuppressive therapy, and EBV seronegativity. It also suggests low-dose immunotherapy and hematopoietic stem-cell transplantation for patients with SIOD.

Indexed as

Epstein-Barr Virus InfectionsHypophosphatemiaImmunologic Deficiency SyndromesKidney TransplantationLymphoproliferative DisordersNephrotic SyndromeOsteochondrodysplasiasPulmonary EmbolismArteriosclerosisChildHerpesvirus 4, HumanHumansImmunocompromised HostImmunosuppressive AgentsMalePrimary Immunodeficiency DiseasesImmunosuppressive Agentsepstein-barr virusinborn error of immunitykidney transplantationpost-transplant lymphoproliferative disorderschimke immunoosseous dysplasia

Identifiers

PMID41624003

DOI10.3389/fimmu.2026.1740720

PMCPMC12852325

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.