Evidence map›Paper›PMID 41623948›Full record

ArticleBiomaterials translational2025

Recombinant human bone morphogenetic protein-2-engineered piezoplatform synergistically promotes bone regeneration through bone morphogenetic protein receptor activation.

Lijie Mao, Dong Zhang, Zehao Shen, Xinqing Wang, Chen Lai, Fangping Chen, Changsheng Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials translational, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Preparation of B@PH/GM-V hydrogel microspheres and their antioxidant and osteogenesis-promoting effects].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lijie MaoEngineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China.
Dong ZhangEngineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China.
Zehao ShenEngineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China.
Xinqing WangEngineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China.
Chen LaiShenzhen Key Laboratory of Human Tissue Regeneration and Repair, PKU-HKUST ShenZhen-HongKong Institution, Shenzhen, Guangdong, China.
Fangping ChenEngineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China.
Changsheng LiuEngineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone morphogenetic protein-2 (BMP-2) is a potent cytokine that promotes bone formation in orthopedic procedures. However, the delivery of recombinant human BMP-2 (rhBMP-2) with sustained release kinetics, while maximizing osteogenic potential, remains a challenge. In this study, we constructed a novel rhBMP-2-engineered piezoplatform for sustained release of rhBMP-2 and synergistic enhancement of osteoinductive activity. The piezoelectric signals are capable of initiating rapid biomineralization and promoting the early adhesion, proliferation, and osteogenic differentiation of bone marrow stromal cells (BMSCs), as well as enabling efficient immobilization and sustained release of rhBMP-2 through electrostatic interactions. Notably, piezoelectric stimulation synergizing with rhBMP-2 enhances osteogenesis-related protein production. This is achieved by amplifying the expression of BMP-2 receptors (

Indexed as

Bone morphogenetic protein receptorsBone regenerationPiezoelectric stimulationRecombinant human bone morphogenetic protein-2

Identifiers

PMID41623948
PMCPMC12852075

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.