Evidence map›Paper›PMID 41623930›Full record

ArticleHemaSphere2026

Immunophenotypic abnormality quantification refines multiparameter flow cytometry-based measurable residual disease testing in adults allografted for acute myeloid leukemia in morphologic remission.

Calvin M Le, Xueyan Chen, Shunya Kodaira, Megan Othus, Margery Gang, Chris Davis, Ryan S Basom, Sindhu Cherian, Roland B Walter

Abstract read
In one paragraph

Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Significance of CD34Transplantation and cellular therapy · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Calvin M LeDepartment of Medicine, Internal Medicine Residency Program, Department of Medicine University of Washington Seattle Washington United States.
Xueyan ChenDepartment of Laboratory Medicine and Pathology University of Washington Seattle Washington United States.
Shunya KodairaPublic Health Science Division Fred Hutchinson Cancer Center Seattle Washington United States.
Megan OthusPublic Health Science Division Fred Hutchinson Cancer Center Seattle Washington United States.
Margery GangHematology/Oncology Fellowship Program Fred Hutchinson Cancer Center/University of Washington Seattle Washington United States.
Chris DavisClinical Research Division Fred Hutchinson Cancer Center Seattle Washington United States.
Ryan S BasomClinical Research Division Fred Hutchinson Cancer Center Seattle Washington United States.
Sindhu CherianDepartment of Laboratory Medicine and Pathology University of Washington Seattle Washington United States.
Roland B WalterDepartment of Laboratory Medicine and Pathology University of Washington Seattle Washington United States.ORCID https://orcid.org/0000-0002-9268-3341

Funding

VIRUS-MEDIATED MYELOSUPPRESSIONP01CA018029 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI STEPHANIE J LEE · 1985 to 2026
$128.4M
RESEARCH TRAINING IN HEMATOLOGYT32HL007093 · NHLBI · UNIVERSITY OF WASHINGTON · PI Janis L Abkowitz · 1985 to 2026
$13.9M
Generating Research Opportunities Within Statistics at Fred Hutch (GROWS@FredHutch)R25CA272187 · NCI · FRED HUTCHINSON CANCER CENTER · PI Jeanne Ting Chowning, RUTH D ETZIONI · 2023 to 2026
$698k
NCI NIH HHS P01 CA018029NCI NIH HHS R25 CA272187NHLBI NIH HHS T32 HL007093
6 · The paper itself

Abstract

Flow cytometry-based measurable residual disease (MRD) testing is routinely used in acute myeloid leukemia (AML), but methodologies need refinement to optimize assay characteristics. Here, we examined 1215 adults with AML or myelodysplastic syndrome/AML allografted in morphologic remission to study how the type(s) of leukemic blasts and degree/number of immunophenotypic abnormalities could improve MRD testing. Among 233 patients with pre-hematopoietic cell transplantation (pre-HCT) MRD, 80 (34%) had non-stem cell-like (NSC-like) leukemic blasts, 109 (47%) had stem cell-like (SC-like) leukemic blasts, and 44 (19%) had NSC- and SC-like leukemic blast cell populations. Across all MRD

Identifiers

PMID41623930
PMCPMC12854164

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.